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Over-the-counter lidocaine cream

Posted on June 19 2018

Lidocaine is popularly used in various numbing medications that are available over-the-counter on the market. Regardless of your need of lidocaine, you must know that not all lidocaine creams are the same - as different creams vary in their lidocaine concentration.

Over-the-counter lidocaine


How does lidocaine work?

Topical lidocaine cream works by reversibly obstructing the nerve conduction close to their site of administration. This causes temporary loss of sensation in a particular area when the cream is applied. The nerve impulse conduction is blocked as the nerve cell membrane permeability is diminished to sodium ions, possibly by while competing with calcium-binding sites that control sodium permeability. The change in permeability reduces depolarization and increases excitability threshold, which further prevents the formation of nerve action potential.


Over-the-counter topical lidocaine creams are used for a variety of skin and mucous membrane conditions, such as tattooing, sunburn, hair removal, minor cosmetic surgeries, hemorrhoids, and laser tattoo removal. A particular type of lidocaine cream in specific concentration depends on its intended use.

Following are some effective and useful lidocaine creams available over-the-counter on the market:

#1. NumbSkin (Lidocaine 5%):

NumbSkin is over-the-counter topical lidocaine cream that includes of 5% active agent Lidocaine. It is water-based, non-oily lidocaine cream, which is registered and certified in the Amerian as well as Worldwide market. The cream provides its maximum numbing effect within a few minutes of its application. It lasts for up to 45 minutes to 1 hour. If needed, you need to reapply, depending on the skin condition and procedure you’re undergoing.

#2. Ebanel Numb 520 (5% Lidocaine):

Ebanel Numb 520 5% Lidocaine is another powerful topical numbing cream. It starts working in just 3 to 5 minutes to relieve pain,discomfort, and burning sensations during some skin procedures. This cream reaches its maximum numbing effect within just twenty minutes and the effect can last for up to an hour.

#3. UberNumb Pain Relief Cream

UberNumb Pain Relief Cream is an incredible 5% lidocaine cream, approved by the FDA in non-prescription creams. The topical numbing cream begins workings immediately after the application, and reaches its peak numbness effect within 20-25 minutes. This numbing cream utilizes a powerful non-oily formula, which makes it perfect for people who are prone to breakouts and other skin problems. Furthermore, the cream is enriched with Vitamin E to not only provide the numbing effect when applied to the site, but also to prevent inflammation and moisturize your skin.

#4. Zensa Maximum Strength Topical Anesthetic Numbing Cream

Zensa Maximum Strength Topical Anesthetic Numbing Cream is another FDA approved solution, which features 5% lidocaine. This numbing cream provides a numbing sensation within a few minutes of application. You just need to apply two layers five minutes apart for maximum effect of the cream. The numbing effect can further last up to three hours. This makes it one of the most effective and long-lasting numbing creams available on the market.

Zensa is used and favored by many tattoo artists, hair removal clinics, as well as various spas throughout the world. Another advantage of this cream is that it doesn’t constrict any blood circulation and this makes it a useful product in body art and ink world.

#5. Numb Master 5% Lidocaine

Numb Master 5% Lidocaine Cream (Topical Anesthetic) is a fast-acting numbing gel that is effective in many skin treatments. It is likely to provide maximum numbing effects within 20-25 minutes and lasts for about an hour. The cream utilizes a strong form of liposomal lidocaine, leading to deeper penetration, and providing a strong numbing effect. Made in the USA, the cream can be applied on the skin up six times a day.

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